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New Books
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Amyloid and Amyloidosis
Added 2/1/2008
Gilles Grateau, Robert Kyle, Martha Skinner
This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, including organ transplants and drug therapies; results from extensive clinical studies; and epidemiology. This is a valuable resource for clinicians who care for patients with systemic and localized forms of amyloidosis, and for researchers in biochemistry, neurobiology, and cell biology.
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Insect Sounds and Communication: Physiology, Behaviour, Ecology, and Evolution
Added 11/1/2007
Sakis Drosopoulos, Michael Claridge
While we may have always assumed that insects employ auditory communication, our understanding of it has been impeded by various technical challenges. In comparison to the study of an insect's visual and olfactory expression, research in the area of acoustic communication has lagged behind. Filling this void, Insect Sounds and Communication is the first multi-author volume to present a comprehensive portrait on this elusive subject. The text includes 32 chapters written by top experts from all corners of the globe.
Divided into two major sections, this groundbreaking text starts with a general introduction to insect sounds and communication that leads into a discussion of the technical aspects of recording and analyzing sounds. It then considers the functioning of the sense organs and sensory systems involved in acoustic behavior, and goes on to investigate the impact that variables such as body size and temperature have on insect sounds and vibrations. Several chapters are devoted to various evolutionary and ecological aspects of insect communication, and include rare information on seldom-studied groups, including Neuropterida and Plecoptera.
The second section of the book includes chapters on communication and song repertoires of a wide diversity of insects, including Heteroptera, Auchenorrhyncha, Psylloidea, Diptera, Coleoptera, and Hymenoptera .
Insect Sounds and Communication is packaged with a DVD, which holds sound and video recordings of many of the insects discussed throughout the text, as well as many full color illustrations not included in the printed text. The DVD also features an unabridged discussion in French of the contribution of the famous French cicadologist, Michel Boulard.
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Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies
Added 1/25/2008
H. John Smith, Claire Simons, Robert E. Sewell
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.
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XIth International Symposium on Amyloidosis
Added 12/27/2007
Martha Skinner, John Berk, Lawreen Connors, David Seldin
Edited by a stellar team of scientists compiling more than 120 papers into a single volume, the XIth Annual International Symposium on Amyloidosis represents the most important review of the state-of-the-science and future directions of this rapidly growing field. An unparalleled cast of pioneering researchers, including keynote speaker and Nobel Laureate Dr. Stanley Prusiner, present groundbreaking research in systemic amyloidosis including the mechanisms of disease and cellular toxicity, AA amyloidosis, familial amyloidosis, AL amyloidosis, clinical trials, and emerging Divided into six sections, the book begins with a study of the mechanisms of fibril formation and cellular response. It investigates possible horizontal transmission, charge differences of deposits in AL and NALCDD, and novel assays to detect amyloid induced apoptosis. The second section considers AA and localized amyloidosis and presents advances in non-invasive imaging, amyloid typing, and the translocation of systemic amyloidosis. The section on familial and TTR amyloidosis features an original report on hereditary gelsolin amyloidosis in an Iranian family, as well as other novel and rare mutations. An extensive section on AL amyloidosis introduces ALBASE as a platform analysis tool, AL amyloidosis in the elderly, and a study of the therapeutic potential of naturally occurring antibodies. Section five focuses on new and emerging diagnostic and translational approaches including characterization and identification through biopsy, mass spectrometry, proteomics, and the use of an amyloid "chip". The book concludes with clinical trials of diflunisal and high dose melphalan-dexamethasone and autologous stem cell transplantation.
translational approaches.
Focusing on new basic and translational medicine approaches in systemic amyloidosis, XIth Annual International Symposium on Amyloidosis provides clinicians and researchers with an invaluable single source reference to the most up-to-date research in the field.
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Neurochemistry of Abused Drugs
Added 12/27/2007
Steven Karch, MD, FFFLM
Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Beginning with a detailed look at individual drugs and their effects on the brain, Neurochemistry of Abused Drugs considers the changes in neurotransmitter levels and discusses the relationship of these changes to the nature and phenomenon of addiction. New studies highlight the addictive capacity of nicotine as well as introduce novel compounds that may aid in tobacco cessation. Chapters examine nicotine dependant neuroplasticity and the various neurochemical substrates that support and promote addiction including cholinergic, dopaminergic, and GABAergic adaptations. The book also offers detailed information on the neurochemical and neurobehavioral consequences of MDMA, methamphetamine, and cocaine use. Recent discoveries on the neurotransmitter systems involved in each of these drugs reveal new therapeutic targets for alleviating addiction including ibogaine, and GABA and glutamate receptors. Extensively referenced and citing numerous up-to-date studies, this book provides unparalleled insight into the action and potential inhibition of drugs of abuse.
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Cortical Areas: Unity and Diversity
Added 2/15/2008
Almut Schuez, Robert Miller
The study of areas in the cerebral cortex has a long history, bringing empirical data into close relation with fundamental conceptual issues about the cortex. The subject is currently being revitalized with the advent of new experimental methods and this book brings a modern perspective to the study of these areas. Cortical Areas: Unity and Diversity explores the correspondence of different methods of mapping areas, the correlation between connectivity and areas, interspecies variations and the developmental origin of areal differences. Cortical areas are also discussed in relation to functional evidence, discussing for instance similarities in cybernetic function between different sensory areas. The book also considers morphological substrates for integration between areas before exploring fundamental questions often asked in neurobiology and brain theory.
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Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology
Added 2/15/2008
Jan Egebjerg, Arne Schousboe, Povl Krogsgaard-Larsen
The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.
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Molecular Pathomechanisms and New Trends in Drug Research
Added 3/14/2008
Gyorgy Keri, Istvan Toth
Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics), and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for novel therapeutic possibilities.
Molecular Pathomechanisms and New Trends in Drug Research presents an in-depth review of the molecular mechanisms involved in a number of common diseases including cancer, AIDS, inflammation, cardiovascular disease and neurodegenerative disorders, with particular emphasis on signal transduction and potential therapeutic strategies. It will be a useful reference text for students and researchers in chemistry, biochemistry, medicine and the pharmaceutical sciences.
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Biological Influences on Criminal Behavior
Added 4/8/2008
Gail Anderson
In reviewing introductory texts available to criminologists, one is left with the impression that biological factors are irrelevant to the formulation of criminal behavior. Where biology is mentioned at all, it receives infinitesimal coverage. This dearth of attention could at one time be blamed on shoddy research and the legitimate fear that evidence gathered along this path would be used to support eugenics extremists. However, in the past 20 years, tremendously valuable work has been accomplished that legitimately correlates biological factors such as genetics, biochemistry, diet, and brain disease to criminal behavior.
Biological Influences on Criminal Behavior fundamentally questions the way most criminologists attempt to explain, let alone ameliorate the problem of human criminal behavior. Written by Gail Anderson, a highly respected expert in forensics, who also brings a much-needed biological background to the task, this resource champions contemporary biological theory by introducing criminologists to areas of research they might not otherwise encounter.
Dr. Anderson discusses basic biological concepts such as natural selection and evolution in relation to behavior, and considers genetic factors including patterns of inheritance, sex-linked traits, and propensities toward aggression. She explores studies on hormonal effects, as well as brain chemistry, and delves deeply into organic brain dysfunction. She also looks at investigations into fetal conditions and birth-related difficulties, as well as research on nutrition and food allergies. While it is steeped in scientific research, the material is presented in a way that does not require a scientific background.
The author does not suggest that biology plays the major role in criminal behavior; however, her carefully researched work does prove that we can gain a far deeper and more useful understanding when we objectively assess all of the factors involved.
A professor of forensic entomology in the School of Criminology at Simon Fraser University, Gail S. Anderson has a Ph.D. in medical and veterinary entomology. She serves as a forensics consultant to the RCMP and city police across Canada. Among her many accolades, she was listed in TIME magazine as one of top five innovators worldwide in criminal justice and recently received the Derome Award from the Canadian Society of Forensic Sciences.
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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
Added 4/28/2008
Wolfgang Liedtke, MD, PH.D.
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels.
While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions.
Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.
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Neurobehavioral Genetics: Methods and Applications, Second Edition
Added 4/28/2008
Byron Jones, Pierre Mormede
A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source.
International researchers incorporate several new developments in the field, including:
· Developmental neurobehavioral genetics
· Gene-gene interaction
· New approaches in bioinformatics
· Gene expression
· Single gene techniques
Based on various studies of living organisms ranging from primates to rodents to invertebrates, this edition offers a contemporary approach to examining the relationship between the genetic mechanisms in the brain and behavior. The authors examine how past and recent advances in methods and knowledge come together in the comparative genetics of behavior. They introduce the reader to experimental approaches available for the genetic study of emotionality, focusing on the use of animal models.
This edition explores studies in neurogenetic disorders, including schizophrenia and bipolar disorders, examines genetic traits in personality such as altruism, and evaluates aggression in mice and humans. It also discusses the applications of quantitative methods and molecular genetics in basic and clinical research.
Neurobehavioral Genetics: Methods and Applications, Second Edition brings together new techniques and methods to promote a better understanding of genetics and their effects on behavior. The book is an excellent resource for investigators who want to incorporate genetic methods into neurobehavioral and psychiatric research.
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Brain Aging: Models, Methods, and Mechanisms
Added 4/28/2008
David Riddle
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur, new possibilities emerge for limiting the effects of aging on neural function. A single source reference is necessary to keep abreast of the recent advances and future directions of gerontology research. Brain Aging: Models, Methods, and Mechanisms offers a selective overview of the current research in this rapidly expanding field. A valuable resource for new and established investigators of the aging brain, this volume reviews critical studies of brain aging in new animal models, as well as advances in brain imaging techniques that permit investigations in aging humans with increasingly higher resolution. Detailed discussions link the information from human and animal studies to illustrate a comprehensive picture of the mechanism of aging. Emphasizing normal brain aging rather than pathological degeneration, the text provides an understanding of fundamental age-related changes in the nervous system and the hypothesis driven research into their bases. The book includes critical analyses of the distinct methodological challenges inherent in investigating the aging nervous system. Contributions from distinguished leaders and pioneers in their respective fields address data and mechanisms, as well as models and methods that are key to the study of aging. Each chapter is extensively referenced and highlights experimental concerns that are magnified or unique to the aging brain. Outlining the newest methods and techniques, Brain Aging: Models, Methods, and Mechanisms provides scientists, researchers, and clinicians with a broad understanding of the important progress and implications for the future of this significant field.
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Amino Acids and Proteins for the Athlete: The Anabolic Edge, Second Edition
Added 5/2/2008
Mauro Di Pasquale
Extensively updated with all chapters rewritten, two entirely new chapters, and double the information and references, Amino Acids and Proteins for the Athlete: The Anabolic Edge, Second Edition reflects the nearly exponential increase in data and knowledge regarding the requirements and functions of amino acids and their role in energy metabolism and metabolic signaling. Expanding the chapter on maximizing body composition and exercise performance to comprise Part II of the book, this second edition gives professional and recreational athletes the tools to improve performance using nutrition and nutritional supplements as alternatives to drug use. Examining the available scientific and medical information in order to determine the physiological and pharmacological effects of protein and amino acids on lean body mass, body fat, strength, and endurance, the author provides a brief review of energy and protein metabolism before describing the positive impact of supplementation on athletic performance, health, disease, and longevity. The book outlines the protein requirements of athletes and the effects of increasing both the amount and quality of dietary protein. It reveals the actions of protein and amino acid supplements on muscle size and strength and energy metabolism and the role of specific amino acid supplements on metabolic and physiological responses to strength and endurance exercises. Specific topics include sources of dietary protein such as vegetarian diets, protein foods vs. supplements, and bioavailability, as well as the actions of amino acids on the central nervous system, the endocrine system, and as hepatoprotectants. Clarifying previously held concepts and addressing new concepts in light of new research, this second edition brings the information on proteins and amino acids up to date, speculates on future directions, and gives solid, practical advice on effective nutritional supplementation.
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